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Literature summary for 5.4.99.22 extracted from
- Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli (2001), RNA, 7, 1603-1615.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D110N | inactive mutant enzyme | Escherichia coli |
| D110T | inactive mutant enzyme | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 23S rRNA uridine2605 | Escherichia coli | - |
23S rRNA pseudouridine2605 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P37765 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 23S rRNA uridine2605 | - |
Escherichia coli | 23S rRNA pseudouridine2605 | - |
? | |
| 23S rRNA uridine2605 | the conserved active site residue Asp110 is essential for activity | Escherichia coli | 23S rRNA pseudouridine2605 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RluB | - |
Escherichia coli |
| YciL | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | no formation of pseudouridine2605 in 23S rRNA of an rluB null mutant. An rluB null mutant or an rluB rluF double null mutant exhibits no obvious growth defect | Escherichia coli |
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Release 2023.1 (January 2023)
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