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BRENDA support

Literature summary for 5.4.99.2 extracted from

  • Chandler, R.J.; Aswani, V.; Tsai, M.S.; Falk, M.; Wehrli, N.; Stabler, S.; Allen, R.; Sedensky, M.; Kazazian, H.H.; Venditti, C.P.
    Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism (2006), Mol. Genet. Metab., 89, 64-73.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine lentiviral delivery of enzyme gene into fibroblasts derived from a patient with mut0 class methylmalonic acidemia can partially restore propionate flux Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information enzyme depletion by RNA interference results in accumulation of methylmalonic acid. Enzyme deletion mutants display reduced propionate incorporation into macromolecules and produce increased amounts of methylmalonic acid in the culture medium. Lentiviral delivery of gene into fibroblasts derived from a patient with mut0 class methylmalonic acidemia can partially restore propionate flux Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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-
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Synonyms

Synonyms Comment Organism
mmcm-1
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Caenorhabditis elegans