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Literature summary for 5.4.99.2 extracted from

  • Fenton, W.A.; Hack, A.M.; Willard, H.F.; Gertler, A.; Rosenberg, L.E.
    Purification and properties of methylmalonyl coenzyme A mutase from human liver (1982), Arch. Biochem. Biophys., 214, 815-823.
    View publication on PubMed

General Stability

General Stability Organism
repeated freezing and thawing results in a gradual loss of activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(R)-2-methyl-3-oxopropanoyl-CoA substrate inhibition Homo sapiens
Ca2+ at high concentrations Homo sapiens
Mg2+ at high concentrations Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5
-
(R)-2-methyl-3-oxopropanoyl-CoA
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cl- stimulates Homo sapiens
PO43- required, maximal activity at 50 mM Homo sapiens
SO42- stimulates Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
77500
-
2 * 77500, SDS-PAGE Homo sapiens
150000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
14
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
-20°C, 1.5 mg protein /ml in 50 mM potassium phosphate, pH 7.4, stable for at least 6 months Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-2-Methyl-3-oxopropanoyl-CoA
-
Homo sapiens ?
-
?
(R)-2-methylmalonyl-CoA
-
Homo sapiens succinyl-CoA
-
?

Subunits

Subunits Comment Organism
dimer 2 * 77500, SDS-PAGE Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
15 min, stable below Homo sapiens
55
-
t1/2: 3 min Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 8
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
cobamide one molecule of enzyme contains about 2 molecules of adenosylcobalamin Homo sapiens