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Literature summary for 5.4.2.8 extracted from
- Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: impact on amphotericin biosynthesis and implications for glycosylation engineering (2009), Metab. Eng., 11, 40-47.
Application
| Application | Comment | Organism |
|---|---|---|
| biotechnology | the double mutant lacking the PMI and PMM genes produces 8-deoxyamphoteronolides in good yields along with trace levels of glycosylated amphotericins, with further genetic engineering these mutants may activate alternative hexoses as GDP-sugars for transfer to aglycones in vivo | Streptomyces nodosus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| DELTAmanAB | phosphomannose isomerase, phosphomannosemutase double mutant | Streptomyces nodosus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-mannose 1-phosphate | Streptomyces nodosus | - |
D-mannose 6-phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces nodosus | B6Z254 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-D-mannose 1-phosphate | - |
Streptomyces nodosus | D-mannose 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphomannomutase | - |
Streptomyces nodosus |
| PMM | - |
Streptomyces nodosus |
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