Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | Rattus norvegicus | - |
Prostaglandin I2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic adventitial fibroblast | - |
Rattus norvegicus | - |
HAoAF cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Prostaglandin H2 | - |
Rattus norvegicus | Prostaglandin I2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGI2 synthase | - |
Rattus norvegicus |
PGIS | - |
Rattus norvegicus |
Prostaglandin I2 synthase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | interleukin-1beta (10 ng/ml, 24 h incubation) does not alter PGIS protein expression | additional information |
Rattus norvegicus | angiotensin II (0.1 mM, 24 h incubation) induces PGIS mRNA expression. Pretreatment with losartan (0.01 mM), PD98059 (0.025 mM) or SB203580 (0.01 mM) prevents PGIS protein expression induced by the combination of angiotensin II and interleukin-1beta | up |