Organism | UniProt | Comment | Textmining |
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Aspergillus tamarii | - |
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Aspergillus tamarii KITA | - |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
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additional information | identification of a putative 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase pathway with the ability to handle both dehydroepiansdrosterone as well as C-17 side-chain containing compounds such as pregnenolone and 3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one. 3beta-HSD/isomerase activity only occurs following lactonization of the steroidal ring-D. Presence of C-7 allylic hydroxylation, in either epimeric form, inhibits 3beta-HSD/isomerase activity. In Aspergillus tamarii, pregnenolone and 3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one are metabolized solely through the putative 3beta-HSD/isomerase pathway | Aspergillus tamarii | ? | - |
? | |
additional information | identification of a putative 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase pathway with the ability to handle both dehydroepiansdrosterone as well as C-17 side-chain containing compounds such as pregnenolone and 3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one. 3beta-HSD/isomerase activity only occurs following lactonization of the steroidal ring-D. Presence of C-7 allylic hydroxylation, in either epimeric form, inhibits 3beta-HSD/isomerase activity. In Aspergillus tamarii, pregnenolone and 3beta-hydroxy-16alpha,17alpha-epoxypregn-5-en-20-one are metabolized solely through the putative 3beta-HSD/isomerase pathway | Aspergillus tamarii KITA | ? | - |
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