Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.1.6 extracted from

  • Roos, A.K.; Burgos, E.; Ericsson, D.J.; Salmon, L.; Mowbray, S.L.
    Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase B reveal new information about the reaction mechanism (2005), J. Biol. Chem., 280, 6416-6422.
    View publication on PubMed
Search for more literature for 5.3.1.6

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapour diffusion method, X-ray structure of ribose-5-phosphate isomerase B in complex with the inhibitors 4-phosphono-D-erythronohydroxamate and 4-phospho-D-erythronate refined to resolutions of 2.1 and 2.2 A Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
4-phospho-D-erythronate
-
 Mycobacterium tuberculosis
4-phosphono-D-erythronohydroxamate
-
 Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8
-
 D-ribose 5-phosphate
-
 Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WKD7
-
-
Mycobacterium tuberculosis H37Rv P9WKD7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-ribose 5-phosphate
-
 Mycobacterium tuberculosis D-ribulose 5-phosphate
-
 ?
D-ribose 5-phosphate
-
 Mycobacterium tuberculosis H37Rv D-ribulose 5-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ribose-5-phosphate isomerase B
-
 Mycobacterium tuberculosis
RpiB
-
 Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.057
-
 4-phosphono-D-erythronohydroxamate
-
 Mycobacterium tuberculosis
1.7
-
 4-phospho-D-erythronate
-
 Mycobacterium tuberculosis