Literature summary for 5.3.1.6 extracted from

Hamada, K.; Ago, H.; Sugahara, M.; Nodake, Y.; Kuramitsu, S.; Miyano, M.
Oxyanion hole-stabilized stereospecific isomerization in ribose-5-phosphate isomerase (Rpi) (2003), J. Biol. Chem., 278, 49183-49190.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure of enzyme complexed with the open chain form of the ribose 5-phosphate and the open chain form of the C2 epimeric inhibitor arabinose 5-phosphate as well as the apo form at high resolution	Thermus thermophilus

Inhibitors

Inhibitors	Comment	Organism	Structure
D-arabinose 5-phosphate	-	Thermus thermophilus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.63	-	D-ribose 5-phosphate	-	Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
D-ribose 5-phosphate	Thermus thermophilus	key enzyme in the oxidative and reductive pentose-phosphate pathway for the conversion of ribose-5-phosphate to ribulose-5-phosphatre and vice versa	D-ribulose 5-phosphate	-	r
D-ribose 5-phosphate	Thermus thermophilus HB8 / ATCC 27634 / DSM 579	key enzyme in the oxidative and reductive pentose-phosphate pathway for the conversion of ribose-5-phosphate to ribulose-5-phosphatre and vice versa	D-ribulose 5-phosphate	-	r

Organism

Organism	UniProt	Comment	Textmining
Thermus thermophilus	-	HB8	-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579	-	HB8	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-ribose 5-phosphate	key enzyme in the oxidative and reductive pentose-phosphate pathway for the conversion of ribose-5-phosphate to ribulose-5-phosphatre and vice versa	Thermus thermophilus	D-ribulose 5-phosphate	-	r
D-ribose 5-phosphate	key enzyme in the oxidative and reductive pentose-phosphate pathway for the conversion of ribose-5-phosphate to ribulose-5-phosphatre and vice versa	Thermus thermophilus HB8 / ATCC 27634 / DSM 579	D-ribulose 5-phosphate	-	r

Synonyms

Synonyms	Comment	Organism
RPI	-	Thermus thermophilus

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1070	-	D-ribose 5-phosphate	50°C, pH 7.5	Thermus thermophilus
1072	-	D-ribose 5-phosphate	50°C, pH 7.5	Thermus thermophilus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.89	-	D-arabinose 5-phosphate	50°C, pH 7.5	Thermus thermophilus

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Release 2023.1 (January 2023)