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Literature summary for 5.3.1.24 extracted from

  • Bode, R.; Birnbaum, D.
    Die Enzyme der Biosynthese aromatischer Aminos„uren bei Hansenula henricii: Phosohoribosyl-Anthranilate-Isomerase und Indolglycerin-Phosphate-Synthase (E:C:4.1.1.48) (1978), Z. Allg. Mikrobiol., 9, 629-635.
No PubMed abstract available
Search for more literature for 5.3.1.24

Inhibitors

Inhibitors Comment Organism Structure
CoCl2 0.001 mM, 20% inhibition Ogataea henricii
CuSO4 0.001 mM, 100% inhibition Ogataea henricii
MnCl2 0.001 mM, 45% inhibition Ogataea henricii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3
-
 N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.6 Ogataea henricii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
185000
-
 indole-3-glycerol-phosphate synthetase/PRA isomerase complex, gel filtration Ogataea henricii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate Ogataea henricii involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate Ogataea henricii CCY 38-10-2 involved in tryptophan biosynthesis from chorismate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Ogataea henricii
-
 bifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex
-
Ogataea henricii CCY 38-10-2
-
 bifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex
-

Purification (Commentary)

Purification (Comment) Organism
21fold Ogataea henricii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0071
-
 pH 7.6 Ogataea henricii

Storage Stability

Storage Stability Organism
4°C, 24h, 35% loss of activity Ogataea henricii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Ogataea henricii 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Ogataea henricii 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate
-
 Ogataea henricii CCY 38-10-2 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?
N-(5-phospho-beta-D-ribosyl)anthranilate involved in tryptophan biosynthesis from chorismate Ogataea henricii CCY 38-10-2 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
-
 Ogataea henricii