Activating Compound | Comment | Organism | Structure |
---|---|---|---|
RhoA | MRDI is induced by RhoA and mediates RhoA-dependent cell invasion | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into pCMV plasmid for expression in mammalian cells and into pMS356 plasmid for esxpression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C168S | inactive mutant | Homo sapiens |
D248A | inactive mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RNAi | stable knockdown of MRDI is carried out in A-375 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-methyl-5-thio-alpha-D-ribose 1-phosphate | Homo sapiens | - |
S-methyl-5-thio-D-ribulose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by nickel-nitrilotriacetic acid affinity chromatography, the His-tag is removed by treatment with tobacco etch virus protease | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-375 cell | - |
Homo sapiens | - |
FOM71 cell | - |
Homo sapiens | - |
FOM78 cell | - |
Homo sapiens | - |
melanocyte cell line | - |
Homo sapiens | - |
melanoma cell line | - |
Homo sapiens | - |
NHEM2493 cell | - |
Homo sapiens | - |
NHEM693 cell | - |
Homo sapiens | - |
WM-35 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-methyl-5-thio-alpha-D-ribose 1-phosphate | - |
Homo sapiens | S-methyl-5-thio-D-ribulose 1-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methylthioribose-1-phosphate isomerase | - |
Homo sapiens |
MRDI | mediator of Rho-dependent invasion | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | RhoA induces expression of MRDI | up |
General Information | Comment | Organism |
---|---|---|
physiological function | MRDI is induced in metastatic cells by constitutive RhoA activation and promotes cell invasion | Homo sapiens |