Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.3.1.1 extracted from

  • Wierenga, R.K.; Kapetaniou, E.G.; Venkatesan, R.
    Triosephosphate isomerase: a highly evolved biocatalyst (2010), Cell. Mol. Life Sci., 67, 3961-3982.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E104D in patients homozygous for this mutation, only 2-20% of TIM catalytic activity is left Homo sapiens
I170V the mutation is asociated with a mild form of TIM deficiency Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bromohydroxyacetone phosphate suicide inhibitor Bartonella henselae
bromohydroxyacetone phosphate suicide inhibitor Caenorhabditis elegans
bromohydroxyacetone phosphate suicide inhibitor Entamoeba histolytica
bromohydroxyacetone phosphate suicide inhibitor Escherichia coli
bromohydroxyacetone phosphate suicide inhibitor Gallus gallus
bromohydroxyacetone phosphate suicide inhibitor Geobacillus stearothermophilus
bromohydroxyacetone phosphate suicide inhibitor Giardia intestinalis
bromohydroxyacetone phosphate suicide inhibitor Helicobacter pylori
bromohydroxyacetone phosphate suicide inhibitor Homo sapiens
bromohydroxyacetone phosphate suicide inhibitor Leishmania mexicana
bromohydroxyacetone phosphate suicide inhibitor Methanocaldococcus jannaschii
bromohydroxyacetone phosphate suicide inhibitor Moritella marina
bromohydroxyacetone phosphate suicide inhibitor Mycobacterium tuberculosis
bromohydroxyacetone phosphate suicide inhibitor Oryctolagus cuniculus
bromohydroxyacetone phosphate suicide inhibitor Plasmodium falciparum
bromohydroxyacetone phosphate suicide inhibitor Pyrococcus woesei
bromohydroxyacetone phosphate suicide inhibitor Saccharomyces cerevisiae
bromohydroxyacetone phosphate suicide inhibitor Tenebrio molitor
bromohydroxyacetone phosphate suicide inhibitor Thermoproteus tenax
bromohydroxyacetone phosphate suicide inhibitor Thermotoga maritima
bromohydroxyacetone phosphate suicide inhibitor Trypanosoma brucei brucei
bromohydroxyacetone phosphate suicide inhibitor Trypanosoma cruzi
DL-glycidol phosphate suicide inhibitor Bartonella henselae
DL-glycidol phosphate suicide inhibitor Caenorhabditis elegans
DL-glycidol phosphate suicide inhibitor Entamoeba histolytica
DL-glycidol phosphate suicide inhibitor Escherichia coli
DL-glycidol phosphate suicide inhibitor Gallus gallus
DL-glycidol phosphate suicide inhibitor Geobacillus stearothermophilus
DL-glycidol phosphate suicide inhibitor Giardia intestinalis
DL-glycidol phosphate suicide inhibitor Helicobacter pylori
DL-glycidol phosphate suicide inhibitor Homo sapiens
DL-glycidol phosphate suicide inhibitor Leishmania mexicana
DL-glycidol phosphate suicide inhibitor Methanocaldococcus jannaschii
DL-glycidol phosphate suicide inhibitor Moritella marina
DL-glycidol phosphate suicide inhibitor Mycobacterium tuberculosis
DL-glycidol phosphate suicide inhibitor Oryctolagus cuniculus
DL-glycidol phosphate suicide inhibitor Plasmodium falciparum
DL-glycidol phosphate suicide inhibitor Pyrococcus woesei
DL-glycidol phosphate suicide inhibitor Saccharomyces cerevisiae
DL-glycidol phosphate suicide inhibitor Tenebrio molitor
DL-glycidol phosphate suicide inhibitor Thermoproteus tenax
DL-glycidol phosphate suicide inhibitor Thermotoga maritima
DL-glycidol phosphate suicide inhibitor Trypanosoma brucei brucei
DL-glycidol phosphate suicide inhibitor Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Helicobacter pylori 5829
-
cytosol
-
Gallus gallus 5829
-
cytosol
-
Tenebrio molitor 5829
-
cytosol
-
Leishmania mexicana 5829
-
cytosol
-
Plasmodium falciparum 5829
-
cytosol
-
Giardia intestinalis 5829
-
cytosol
-
Methanocaldococcus jannaschii 5829
-
cytosol
-
Moritella marina 5829
-
cytosol
-
Mycobacterium tuberculosis 5829
-
cytosol
-
Oryctolagus cuniculus 5829
-
cytosol
-
Pyrococcus woesei 5829
-
cytosol
-
Saccharomyces cerevisiae 5829
-
cytosol
-
Trypanosoma brucei brucei 5829
-
cytosol
-
Thermotoga maritima 5829
-
cytosol
-
Thermoproteus tenax 5829
-
cytosol
-
Bartonella henselae 5829
-
cytosol
-
Geobacillus stearothermophilus 5829
-
cytosol
-
Caenorhabditis elegans 5829
-
cytosol
-
Escherichia coli 5829
-
cytosol
-
Entamoeba histolytica 5829
-
glycosome
-
Trypanosoma cruzi 20015
-

Organism

Organism UniProt Comment Textmining
Bartonella henselae Q8L1Z5
-
-
Caenorhabditis elegans Q10657
-
-
Entamoeba histolytica O02611
-
-
Escherichia coli P0A858
-
-
Gallus gallus P00940
-
-
Geobacillus stearothermophilus P00943
-
-
Giardia intestinalis P36186
-
-
Helicobacter pylori P56076
-
-
Homo sapiens P60174
-
-
Leishmania mexicana P48499
-
-
Methanocaldococcus jannaschii Q58923
-
-
Moritella marina P50921
-
-
Mycobacterium tuberculosis P9WG43
-
-
Mycobacterium tuberculosis H37Rv P9WG43
-
-
Oryctolagus cuniculus P00939
-
-
Plasmodium falciparum Q07412
-
-
Pyrococcus woesei P62003
-
-
Saccharomyces cerevisiae P00942
-
-
Tenebrio molitor Q8MPF2
-
-
Thermoproteus tenax Q8NKN9
-
-
Thermotoga maritima P36204 bifunctional enzyme, phosphoglycerate kinase/triosephosphate isomerase
-
Trypanosoma brucei brucei P04789
-
-
Trypanosoma cruzi P52270
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate
-
Homo sapiens dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Helicobacter pylori dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Gallus gallus dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Tenebrio molitor dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Leishmania mexicana dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Plasmodium falciparum dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Giardia intestinalis dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Methanocaldococcus jannaschii dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Moritella marina dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Mycobacterium tuberculosis dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Oryctolagus cuniculus dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Pyrococcus woesei dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Saccharomyces cerevisiae dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Trypanosoma brucei brucei dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Trypanosoma cruzi dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Thermotoga maritima dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Thermoproteus tenax dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Bartonella henselae dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Geobacillus stearothermophilus dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Caenorhabditis elegans dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Escherichia coli dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Entamoeba histolytica dihydroxyacetone phosphate
-
r
D-glyceraldehyde 3-phosphate
-
Mycobacterium tuberculosis H37Rv dihydroxyacetone phosphate
-
r

Subunits

Subunits Comment Organism
dimer X-ray crystallography, only the TIM dimer is fully active Homo sapiens
dimer X-ray crystallography, only the TIM dimer is fully active Helicobacter pylori
dimer X-ray crystallography, only the TIM dimer is fully active Gallus gallus
dimer X-ray crystallography, only the TIM dimer is fully active Tenebrio molitor
dimer X-ray crystallography, only the TIM dimer is fully active Leishmania mexicana
dimer X-ray crystallography, only the TIM dimer is fully active Plasmodium falciparum
dimer X-ray crystallography, only the TIM dimer is fully active Giardia intestinalis
dimer X-ray crystallography, only the TIM dimer is fully active Methanocaldococcus jannaschii
dimer X-ray crystallography, only the TIM dimer is fully active Moritella marina
dimer X-ray crystallography, only the TIM dimer is fully active Mycobacterium tuberculosis
dimer X-ray crystallography, only the TIM dimer is fully active Oryctolagus cuniculus
dimer X-ray crystallography, only the TIM dimer is fully active Pyrococcus woesei
dimer X-ray crystallography, only the TIM dimer is fully active Saccharomyces cerevisiae
dimer X-ray crystallography, only the TIM dimer is fully active Trypanosoma brucei brucei
dimer X-ray crystallography, only the TIM dimer is fully active Trypanosoma cruzi
dimer X-ray crystallography, only the TIM dimer is fully active Thermotoga maritima
dimer X-ray crystallography, only the TIM dimer is fully active Thermoproteus tenax
dimer X-ray crystallography, only the TIM dimer is fully active Bartonella henselae
dimer X-ray crystallography, only the TIM dimer is fully active Geobacillus stearothermophilus
dimer X-ray crystallography, only the TIM dimer is fully active Caenorhabditis elegans
dimer X-ray crystallography, only the TIM dimer is fully active Escherichia coli
dimer X-ray crystallography, only the TIM dimer is fully active Entamoeba histolytica

Synonyms

Synonyms Comment Organism
TIM
-
Homo sapiens
TIM
-
Helicobacter pylori
TIM
-
Gallus gallus
TIM
-
Tenebrio molitor
TIM
-
Leishmania mexicana
TIM
-
Plasmodium falciparum
TIM
-
Giardia intestinalis
TIM
-
Methanocaldococcus jannaschii
TIM
-
Moritella marina
TIM
-
Mycobacterium tuberculosis
TIM
-
Oryctolagus cuniculus
TIM
-
Pyrococcus woesei
TIM
-
Saccharomyces cerevisiae
TIM
-
Trypanosoma brucei brucei
TIM
-
Trypanosoma cruzi
TIM
-
Thermotoga maritima
TIM
-
Thermoproteus tenax
TIM
-
Bartonella henselae
TIM
-
Geobacillus stearothermophilus
TIM
-
Caenorhabditis elegans
TIM
-
Escherichia coli
TIM
-
Entamoeba histolytica
Triosephosphate isomerase
-
Homo sapiens
Triosephosphate isomerase
-
Helicobacter pylori
Triosephosphate isomerase
-
Gallus gallus
Triosephosphate isomerase
-
Tenebrio molitor
Triosephosphate isomerase
-
Leishmania mexicana
Triosephosphate isomerase
-
Plasmodium falciparum
Triosephosphate isomerase
-
Giardia intestinalis
Triosephosphate isomerase
-
Methanocaldococcus jannaschii
Triosephosphate isomerase
-
Moritella marina
Triosephosphate isomerase
-
Mycobacterium tuberculosis
Triosephosphate isomerase
-
Oryctolagus cuniculus
Triosephosphate isomerase
-
Pyrococcus woesei
Triosephosphate isomerase
-
Saccharomyces cerevisiae
Triosephosphate isomerase
-
Trypanosoma brucei brucei
Triosephosphate isomerase
-
Trypanosoma cruzi
Triosephosphate isomerase
-
Thermotoga maritima
Triosephosphate isomerase
-
Thermoproteus tenax
Triosephosphate isomerase
-
Bartonella henselae
Triosephosphate isomerase
-
Geobacillus stearothermophilus
Triosephosphate isomerase
-
Caenorhabditis elegans
Triosephosphate isomerase
-
Escherichia coli
Triosephosphate isomerase
-
Entamoeba histolytica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
optimum is near pH 8.0 Homo sapiens
8
-
optimum is near pH 8.0 Helicobacter pylori
8
-
optimum is near pH 8.0 Gallus gallus
8
-
optimum is near pH 8.0 Tenebrio molitor
8
-
optimum is near pH 8.0 Leishmania mexicana
8
-
optimum is near pH 8.0 Plasmodium falciparum
8
-
optimum is near pH 8.0 Giardia intestinalis
8
-
optimum is near pH 8.0 Methanocaldococcus jannaschii
8
-
optimum is near pH 8.0 Moritella marina
8
-
optimum is near pH 8.0 Mycobacterium tuberculosis
8
-
optimum is near pH 8.0 Oryctolagus cuniculus
8
-
optimum is near pH 8.0 Pyrococcus woesei
8
-
optimum is near pH 8.0 Saccharomyces cerevisiae
8
-
optimum is near pH 8.0 Trypanosoma brucei brucei
8
-
optimum is near pH 8.0 Trypanosoma cruzi
8
-
optimum is near pH 8.0 Thermotoga maritima
8
-
optimum is near pH 8.0 Thermoproteus tenax
8
-
optimum is near pH 8.0 Bartonella henselae
8
-
optimum is near pH 8.0 Geobacillus stearothermophilus
8
-
optimum is near pH 8.0 Caenorhabditis elegans
8
-
optimum is near pH 8.0 Escherichia coli
8
-
optimum is near pH 8.0 Entamoeba histolytica

General Information

General Information Comment Organism
malfunction TIM deficiency is the only human glycolytic deficiency disease which is lethal, usually in early childhood. The disease symptoms concern hemolytic anemia but also neurological disorders Homo sapiens