Protein Variants | Comment | Organism |
---|---|---|
E104D | in patients homozygous for this mutation, only 2-20% of TIM catalytic activity is left | Homo sapiens |
I170V | the mutation is asociated with a mild form of TIM deficiency | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bromohydroxyacetone phosphate | suicide inhibitor | Bartonella henselae | |
bromohydroxyacetone phosphate | suicide inhibitor | Caenorhabditis elegans | |
bromohydroxyacetone phosphate | suicide inhibitor | Entamoeba histolytica | |
bromohydroxyacetone phosphate | suicide inhibitor | Escherichia coli | |
bromohydroxyacetone phosphate | suicide inhibitor | Gallus gallus | |
bromohydroxyacetone phosphate | suicide inhibitor | Geobacillus stearothermophilus | |
bromohydroxyacetone phosphate | suicide inhibitor | Giardia intestinalis | |
bromohydroxyacetone phosphate | suicide inhibitor | Helicobacter pylori | |
bromohydroxyacetone phosphate | suicide inhibitor | Homo sapiens | |
bromohydroxyacetone phosphate | suicide inhibitor | Leishmania mexicana | |
bromohydroxyacetone phosphate | suicide inhibitor | Methanocaldococcus jannaschii | |
bromohydroxyacetone phosphate | suicide inhibitor | Moritella marina | |
bromohydroxyacetone phosphate | suicide inhibitor | Mycobacterium tuberculosis | |
bromohydroxyacetone phosphate | suicide inhibitor | Oryctolagus cuniculus | |
bromohydroxyacetone phosphate | suicide inhibitor | Plasmodium falciparum | |
bromohydroxyacetone phosphate | suicide inhibitor | Pyrococcus woesei | |
bromohydroxyacetone phosphate | suicide inhibitor | Saccharomyces cerevisiae | |
bromohydroxyacetone phosphate | suicide inhibitor | Tenebrio molitor | |
bromohydroxyacetone phosphate | suicide inhibitor | Thermoproteus tenax | |
bromohydroxyacetone phosphate | suicide inhibitor | Thermotoga maritima | |
bromohydroxyacetone phosphate | suicide inhibitor | Trypanosoma brucei brucei | |
bromohydroxyacetone phosphate | suicide inhibitor | Trypanosoma cruzi | |
DL-glycidol phosphate | suicide inhibitor | Bartonella henselae | |
DL-glycidol phosphate | suicide inhibitor | Caenorhabditis elegans | |
DL-glycidol phosphate | suicide inhibitor | Entamoeba histolytica | |
DL-glycidol phosphate | suicide inhibitor | Escherichia coli | |
DL-glycidol phosphate | suicide inhibitor | Gallus gallus | |
DL-glycidol phosphate | suicide inhibitor | Geobacillus stearothermophilus | |
DL-glycidol phosphate | suicide inhibitor | Giardia intestinalis | |
DL-glycidol phosphate | suicide inhibitor | Helicobacter pylori | |
DL-glycidol phosphate | suicide inhibitor | Homo sapiens | |
DL-glycidol phosphate | suicide inhibitor | Leishmania mexicana | |
DL-glycidol phosphate | suicide inhibitor | Methanocaldococcus jannaschii | |
DL-glycidol phosphate | suicide inhibitor | Moritella marina | |
DL-glycidol phosphate | suicide inhibitor | Mycobacterium tuberculosis | |
DL-glycidol phosphate | suicide inhibitor | Oryctolagus cuniculus | |
DL-glycidol phosphate | suicide inhibitor | Plasmodium falciparum | |
DL-glycidol phosphate | suicide inhibitor | Pyrococcus woesei | |
DL-glycidol phosphate | suicide inhibitor | Saccharomyces cerevisiae | |
DL-glycidol phosphate | suicide inhibitor | Tenebrio molitor | |
DL-glycidol phosphate | suicide inhibitor | Thermoproteus tenax | |
DL-glycidol phosphate | suicide inhibitor | Thermotoga maritima | |
DL-glycidol phosphate | suicide inhibitor | Trypanosoma brucei brucei | |
DL-glycidol phosphate | suicide inhibitor | Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Helicobacter pylori | 5829 | - |
cytosol | - |
Gallus gallus | 5829 | - |
cytosol | - |
Tenebrio molitor | 5829 | - |
cytosol | - |
Leishmania mexicana | 5829 | - |
cytosol | - |
Plasmodium falciparum | 5829 | - |
cytosol | - |
Giardia intestinalis | 5829 | - |
cytosol | - |
Methanocaldococcus jannaschii | 5829 | - |
cytosol | - |
Moritella marina | 5829 | - |
cytosol | - |
Mycobacterium tuberculosis | 5829 | - |
cytosol | - |
Oryctolagus cuniculus | 5829 | - |
cytosol | - |
Pyrococcus woesei | 5829 | - |
cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
cytosol | - |
Trypanosoma brucei brucei | 5829 | - |
cytosol | - |
Thermotoga maritima | 5829 | - |
cytosol | - |
Thermoproteus tenax | 5829 | - |
cytosol | - |
Bartonella henselae | 5829 | - |
cytosol | - |
Geobacillus stearothermophilus | 5829 | - |
cytosol | - |
Caenorhabditis elegans | 5829 | - |
cytosol | - |
Escherichia coli | 5829 | - |
cytosol | - |
Entamoeba histolytica | 5829 | - |
glycosome | - |
Trypanosoma cruzi | 20015 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bartonella henselae | Q8L1Z5 | - |
- |
Caenorhabditis elegans | Q10657 | - |
- |
Entamoeba histolytica | O02611 | - |
- |
Escherichia coli | P0A858 | - |
- |
Gallus gallus | P00940 | - |
- |
Geobacillus stearothermophilus | P00943 | - |
- |
Giardia intestinalis | P36186 | - |
- |
Helicobacter pylori | P56076 | - |
- |
Homo sapiens | P60174 | - |
- |
Leishmania mexicana | P48499 | - |
- |
Methanocaldococcus jannaschii | Q58923 | - |
- |
Moritella marina | P50921 | - |
- |
Mycobacterium tuberculosis | P9WG43 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WG43 | - |
- |
Oryctolagus cuniculus | P00939 | - |
- |
Plasmodium falciparum | Q07412 | - |
- |
Pyrococcus woesei | P62003 | - |
- |
Saccharomyces cerevisiae | P00942 | - |
- |
Tenebrio molitor | Q8MPF2 | - |
- |
Thermoproteus tenax | Q8NKN9 | - |
- |
Thermotoga maritima | P36204 | bifunctional enzyme, phosphoglycerate kinase/triosephosphate isomerase | - |
Trypanosoma brucei brucei | P04789 | - |
- |
Trypanosoma cruzi | P52270 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glyceraldehyde 3-phosphate | - |
Homo sapiens | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Helicobacter pylori | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Gallus gallus | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Tenebrio molitor | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Leishmania mexicana | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Plasmodium falciparum | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Giardia intestinalis | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Methanocaldococcus jannaschii | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Moritella marina | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Mycobacterium tuberculosis | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Oryctolagus cuniculus | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Pyrococcus woesei | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Saccharomyces cerevisiae | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Trypanosoma brucei brucei | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Trypanosoma cruzi | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Thermotoga maritima | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Thermoproteus tenax | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Bartonella henselae | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Geobacillus stearothermophilus | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Caenorhabditis elegans | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Escherichia coli | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Entamoeba histolytica | dihydroxyacetone phosphate | - |
r | |
D-glyceraldehyde 3-phosphate | - |
Mycobacterium tuberculosis H37Rv | dihydroxyacetone phosphate | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | X-ray crystallography, only the TIM dimer is fully active | Homo sapiens |
dimer | X-ray crystallography, only the TIM dimer is fully active | Helicobacter pylori |
dimer | X-ray crystallography, only the TIM dimer is fully active | Gallus gallus |
dimer | X-ray crystallography, only the TIM dimer is fully active | Tenebrio molitor |
dimer | X-ray crystallography, only the TIM dimer is fully active | Leishmania mexicana |
dimer | X-ray crystallography, only the TIM dimer is fully active | Plasmodium falciparum |
dimer | X-ray crystallography, only the TIM dimer is fully active | Giardia intestinalis |
dimer | X-ray crystallography, only the TIM dimer is fully active | Methanocaldococcus jannaschii |
dimer | X-ray crystallography, only the TIM dimer is fully active | Moritella marina |
dimer | X-ray crystallography, only the TIM dimer is fully active | Mycobacterium tuberculosis |
dimer | X-ray crystallography, only the TIM dimer is fully active | Oryctolagus cuniculus |
dimer | X-ray crystallography, only the TIM dimer is fully active | Pyrococcus woesei |
dimer | X-ray crystallography, only the TIM dimer is fully active | Saccharomyces cerevisiae |
dimer | X-ray crystallography, only the TIM dimer is fully active | Trypanosoma brucei brucei |
dimer | X-ray crystallography, only the TIM dimer is fully active | Trypanosoma cruzi |
dimer | X-ray crystallography, only the TIM dimer is fully active | Thermotoga maritima |
dimer | X-ray crystallography, only the TIM dimer is fully active | Thermoproteus tenax |
dimer | X-ray crystallography, only the TIM dimer is fully active | Bartonella henselae |
dimer | X-ray crystallography, only the TIM dimer is fully active | Geobacillus stearothermophilus |
dimer | X-ray crystallography, only the TIM dimer is fully active | Caenorhabditis elegans |
dimer | X-ray crystallography, only the TIM dimer is fully active | Escherichia coli |
dimer | X-ray crystallography, only the TIM dimer is fully active | Entamoeba histolytica |
Synonyms | Comment | Organism |
---|---|---|
TIM | - |
Homo sapiens |
TIM | - |
Helicobacter pylori |
TIM | - |
Gallus gallus |
TIM | - |
Tenebrio molitor |
TIM | - |
Leishmania mexicana |
TIM | - |
Plasmodium falciparum |
TIM | - |
Giardia intestinalis |
TIM | - |
Methanocaldococcus jannaschii |
TIM | - |
Moritella marina |
TIM | - |
Mycobacterium tuberculosis |
TIM | - |
Oryctolagus cuniculus |
TIM | - |
Pyrococcus woesei |
TIM | - |
Saccharomyces cerevisiae |
TIM | - |
Trypanosoma brucei brucei |
TIM | - |
Trypanosoma cruzi |
TIM | - |
Thermotoga maritima |
TIM | - |
Thermoproteus tenax |
TIM | - |
Bartonella henselae |
TIM | - |
Geobacillus stearothermophilus |
TIM | - |
Caenorhabditis elegans |
TIM | - |
Escherichia coli |
TIM | - |
Entamoeba histolytica |
Triosephosphate isomerase | - |
Homo sapiens |
Triosephosphate isomerase | - |
Helicobacter pylori |
Triosephosphate isomerase | - |
Gallus gallus |
Triosephosphate isomerase | - |
Tenebrio molitor |
Triosephosphate isomerase | - |
Leishmania mexicana |
Triosephosphate isomerase | - |
Plasmodium falciparum |
Triosephosphate isomerase | - |
Giardia intestinalis |
Triosephosphate isomerase | - |
Methanocaldococcus jannaschii |
Triosephosphate isomerase | - |
Moritella marina |
Triosephosphate isomerase | - |
Mycobacterium tuberculosis |
Triosephosphate isomerase | - |
Oryctolagus cuniculus |
Triosephosphate isomerase | - |
Pyrococcus woesei |
Triosephosphate isomerase | - |
Saccharomyces cerevisiae |
Triosephosphate isomerase | - |
Trypanosoma brucei brucei |
Triosephosphate isomerase | - |
Trypanosoma cruzi |
Triosephosphate isomerase | - |
Thermotoga maritima |
Triosephosphate isomerase | - |
Thermoproteus tenax |
Triosephosphate isomerase | - |
Bartonella henselae |
Triosephosphate isomerase | - |
Geobacillus stearothermophilus |
Triosephosphate isomerase | - |
Caenorhabditis elegans |
Triosephosphate isomerase | - |
Escherichia coli |
Triosephosphate isomerase | - |
Entamoeba histolytica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
optimum is near pH 8.0 | Homo sapiens |
8 | - |
optimum is near pH 8.0 | Helicobacter pylori |
8 | - |
optimum is near pH 8.0 | Gallus gallus |
8 | - |
optimum is near pH 8.0 | Tenebrio molitor |
8 | - |
optimum is near pH 8.0 | Leishmania mexicana |
8 | - |
optimum is near pH 8.0 | Plasmodium falciparum |
8 | - |
optimum is near pH 8.0 | Giardia intestinalis |
8 | - |
optimum is near pH 8.0 | Methanocaldococcus jannaschii |
8 | - |
optimum is near pH 8.0 | Moritella marina |
8 | - |
optimum is near pH 8.0 | Mycobacterium tuberculosis |
8 | - |
optimum is near pH 8.0 | Oryctolagus cuniculus |
8 | - |
optimum is near pH 8.0 | Pyrococcus woesei |
8 | - |
optimum is near pH 8.0 | Saccharomyces cerevisiae |
8 | - |
optimum is near pH 8.0 | Trypanosoma brucei brucei |
8 | - |
optimum is near pH 8.0 | Trypanosoma cruzi |
8 | - |
optimum is near pH 8.0 | Thermotoga maritima |
8 | - |
optimum is near pH 8.0 | Thermoproteus tenax |
8 | - |
optimum is near pH 8.0 | Bartonella henselae |
8 | - |
optimum is near pH 8.0 | Geobacillus stearothermophilus |
8 | - |
optimum is near pH 8.0 | Caenorhabditis elegans |
8 | - |
optimum is near pH 8.0 | Escherichia coli |
8 | - |
optimum is near pH 8.0 | Entamoeba histolytica |
General Information | Comment | Organism |
---|---|---|
malfunction | TIM deficiency is the only human glycolytic deficiency disease which is lethal, usually in early childhood. The disease symptoms concern hemolytic anemia but also neurological disorders | Homo sapiens |