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Literature summary for 5.3.1.1 extracted from
- Triosephosphate isomerase from human erythrocytes (1975), Methods Enzymol., 41B, 442-447.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AsO43- | competitive | Homo sapiens |  |
| ATP | - |
Homo sapiens | |
| Chloroacetol phosphate | - |
Homo sapiens | |
| D-alpha-glycerophosphate | competitive | Homo sapiens | |
| Phosphoglycolate | competitive | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.34 | - |
D-glyceraldehyde 3-phosphate | enzyme form I | Homo sapiens | |
| 0.43 | - |
D-glyceraldehyde 3-phosphate | enzyme form II | Homo sapiens | |
| 0.55 | - |
D-glyceraldehyde 3-phosphate | enzyme form III | Homo sapiens | |
| 0.69 | - |
glycerone phosphate | enzyme form III | Homo sapiens | |
| 0.82 | - |
glycerone phosphate | enzyme form II | Homo sapiens | |
| 1.5 | - |
glycerone phosphate | enzyme form I | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 3 distinct electrophoretic forms: I, II, III | Homo sapiens |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| renaturation into catalytic active enzyme by removal of the dissociating agent | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| muscle | skeletal | Homo sapiens | - |
| muscle | cardiac | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 10240 | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Glyceraldehyde 3-phosphate | r | Homo sapiens | Glycerone phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | two types of subunits possess similar but distinguishable amino acid composition, 3 electrophorectic forms: AA, AB, BB | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9.5 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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