Cloned (Comment) | Organism |
---|---|
gene ROF2, overexpression in transgenic Arabidopsis thaliana lines | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of ROF2 confers tolerance to intracellular acidification by increasing proton extrusion from cells. Expression of ROF2 activates K+ uptake, causing depolarization of the plasma membrane, which activates the electrogenic plasma membrane proton pump, H+-ATPase | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FK506 | - |
Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
intracellular | - |
Arabidopsis thaliana | 5622 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q9FJL3 | gene ROF2 | - |
Synonyms | Comment | Organism |
---|---|---|
Peptidyl-prolyl cis-trans isomerase | - |
Arabidopsis thaliana |
ROF2 | - |
Arabidopsis thaliana |
Organism | Comment | Expression |
---|---|---|
Arabidopsis thaliana | intracellular acid stress generated by weak organic acids at normal external pH induces expression of several chaperone genes, including ROF2 | up |
General Information | Comment | Organism |
---|---|---|
evolution | ROF2 encodes a peptidyl-prolyl cis-trans isomerase of the FK506-binding protein class | Arabidopsis thaliana |
malfunction | loss of function of ROF2, and especially double mutation of ROF2 and the closely related gene ROF1, results in acid sensitivity, stress and development phenotypes of ROF mutants, overview | Arabidopsis thaliana |
additional information | ROF2 overexpressing plants show tolerance to toxic cations such as lithium, norspermidine and hygromycin B, whose uptake is driven by the membrane potential, due to activation of the electrogenic plasma membrane proton pump, ROF2 activates K+ transport, H+-ATPase, phenotypes, overview | Arabidopsis thaliana |
physiological function | peptidyl-prolyl cis-trans isomerase ROF2 modulates intracellular pH homeostasis. As ROF2 induction and intracellular acidification are common consequences of many stresses, this mechanism of pH homeostasis may be of general importance for stress tolerance. Chaperone ROF2 not only helps to refold proteins but also activates H+ extrusion to restore intracellular pH | Arabidopsis thaliana |