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Literature summary for 5.2.1.8 extracted from

  • Fan, G.; Fan, Y.; Gupta, N.; Matsuura, I.; Liu, F.; Zhou, X.Z.; Lu, K.P.; Gelinas, C.
    Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family (2009), Cancer Res., 69, 4589-4597.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Application

Application Comment Organism
pharmacology Pin1 is a potential therapeutic target in Rel/NF-kappaB-dependent leukemia/lymphomas Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a WW domain mutant of Pin1 can no longer interact with NF-kappaB Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
juglone Pin1 inhibition leads to relocalization of endogenous c-Rel to the cytoplasm coincident with lymphoma cell death and/or growth inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Pin1 interacts with NF-kappaB via its WW domain ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell lymphoma cell
-
 Homo sapiens
-
carcinoma cell the enzyme is upregulated in cancer cells Homo sapiens
-
KM-H2 cell a Hodkin's lymphoma cell line Homo sapiens
-
lymphocyte primary Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Pin1 interacts with NF-kappaB via its WW domain Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
peptidyl-prolyl isomerase
-
 Homo sapiens
Pin1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated in cancer cells up

General Information

General Information Comment Organism
physiological function Pin1 markedly enhances transformation in primary lymphocytes by the c-Rel protein and by viral Rel/NF-kappaB oncoprotein v-Rel, it enhances the nuclear translocation of the Rel proteins, overview Homo sapiens