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Literature summary for 5.2.1.8 extracted from

  • Kenyon, W.J.; Humphreys, S.; Roberts, M.; Spector, M.P.
    Periplasmic peptidyl-prolyl isomerases SurA and FkpA play an important role in the starvation-stress response (SSR) of Salmonella enterica serovar Typhimurium (2010), Antonie van Leeuwenhoek, 98, 51-63.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information disruption of the fkpA gene results in a 47.9fold and 32.1fold decrease in thermotolerance in 5-h and 24-h CS cells, respectively, compared to the parental strain Salmonella enterica subsp. enterica serovar Typhimurium

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasm
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Salmonella enterica subsp. enterica serovar Typhimurium
-
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Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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strains C5 and SL1344, genes surA and fkpA. SurA can functionally compensate for the absence of FkpA, but when SurA is missing, or especially when both SurA and FkpA are missing, the ability of cells to survive or recover from prolonged periods of C-starvation is significantly impaired
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture carbon-starved cells Salmonella enterica subsp. enterica serovar Typhimurium
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Synonyms

Synonyms Comment Organism
FkpA
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Salmonella enterica subsp. enterica serovar Typhimurium
peptidyl-prolyl isomerase
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Salmonella enterica subsp. enterica serovar Typhimurium
SurA
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Salmonella enterica subsp. enterica serovar Typhimurium

Expression

Organism Comment Expression
Salmonella enterica subsp. enterica serovar Typhimurium genes surA and fkpA are not carbon energy source-starvation inducible, and their expression during C-starvation does not appear to be sigmaE-dependent, overview additional information

General Information

General Information Comment Organism
additional information SurA and FkpA are not involved in the starvation-stress response, SSR. Genes surA and fkpA appear to be dispensable for the cross-resistance of carbon-starved cells to oxidative stress Salmonella enterica subsp. enterica serovar Typhimurium
physiological function SurA may function to repair, or prevent damage to, the outer membrane upon exposure to PmB and may consequently limit damage to the inner-membrane Salmonella enterica subsp. enterica serovar Typhimurium