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Literature summary for 5.2.1.8 extracted from

  • Peng, H.; Vijayakumar, S.; Schiene-Fischer, C.; Li, H.; Purkerson, J.M.; Malesevic, M.; Liebscher, J.; Al-Awqati, Q.; Schwartz, G.J.
    Secreted cyclophilin A, a peptidyl prolyl cis/trans isomerase, mediates matrix assembly of hensin, a protein implicated in epithelial differentiation (2008), J. Biol. Chem., 284, 6465-6475.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
cyclosporin A and cyclosporin derivative with modifications in the D-Ser side chain. Inhibition leads to failure of polymerization of the extracellular multi-domain protein hensin, plus the loss of the apical cytoskeleton, apical microvilli, and the columnar epithelial shape of clone C cells Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Oryctolagus cuniculus cyclophilin A mediates the polymerization and matrix assembly of hensin, a multifunctional, multi-domain protein implicated in the regulation of epithelial differentiation ?
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Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus Q9TTC6 isoform cyclophilin A
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cyclophilin A mediates the polymerization and matrix assembly of hensin, a multifunctional, multi-domain protein implicated in the regulation of epithelial differentiation Oryctolagus cuniculus ?
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 ?