Literature summary for 5.2.1.8 extracted from

Dourlen, P.; Ando, K.; Hamdane, M.; Begard, S.; Buee, L.; Galas, M.C.
The peptidyl prolyl cis/trans isomerase Pin1 downregulates the inhibitor of apoptosis protein Survivin (2007), Biochim. Biophys. Acta, 1773, 1428-1437.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS-1 cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	Pin1 and the inhibitor of apoptosis protein, Survivin partially co-localize in interphase and mitotic cells	Homo sapiens	5737	-
nucleus	Pin1 and the inhibitor of apoptosis protein, Survivin partially co-localize in interphase and mitotic cells	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13526	isoform Pin1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuroblastoma cell	-	Homo sapiens	-
SH-SY5Y cell	neuroblastoma cell, overexpression of isoform Pin1 decreases levels of the inhibitor of apoptosis protein, Survivin. Pin1 and Survivin partially co-localize in interphase and mitotic cells and form a complex. Pin1 silencing leads to an increase in Survivin levels	Homo sapiens	-

Subunits

Subunits	Comment	Organism
More	isoform Pin1 forms a complex with inhibitor of apoptosis protein, Survivin	Homo sapiens

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Release 2023.1 (January 2023)