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Literature summary for 5.2.1.8 extracted from

  • Wang, H.C.; Kim, K.; Bakhtiar, R.; Germanas, J.P.
    Structure-activity studies of ground- and transition-State analogue inhibitors of cyclophilin (2001), J. Med. Chem., 44, 2593-2600.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(6,8aR)-6-N,N-monophenylimino-8a-carboxyindolizidin-5-one methyl ester dissociation constant: above 0.2 mM Escherichia coli
(6R,8a,R)-6-(2-methylnaphthyl)-N-tert-butoxycarbonyl-6-amino-8a-carboxyindolizidin-5-one methyl ester dissociation constant: 0.017 mM Escherichia coli
(6R,8aR)-6-(2-methylnaphthyl)-N-acetyl-6-amino-8a-carboxyindolizidin-5-one methyl ester dissociation constant: 0.0015 mM Escherichia coli
(6R,8aR)-6-(2-methylnaphthyl)-N-benzyloxycarbonyl-6-amino-8a-carboxyindolizidin-5-one methyl ester dissociation constant: 0.047 mM Escherichia coli
(6R,8aR)-6-(2-methylnaphthyl)-N-tert-butoxycarbonyl-6-amino-8a-indolizidine methyl ester dissociation constant: 0.077 mM Escherichia coli
(6R,8aR)-6-benzyl-6-N-tert-butoxycarbonylamino-8a-carboxyindolizidin-5-one methyl ester dissociation constant: 0.14 mM Escherichia coli
(6R,8aR)-6-benzyl-N-benzyloxycarbonyl-6-amino-8a-carboxyindolizidin-5-one methyl ester dissociation constant: 0.124 mM Escherichia coli
(6R,8aR)-6-N-tert-butoxycarbonylamino-8a-carboxyindolizidine methyl ester dissociation constant: 0.2 mM Escherichia coli
(6S,8aR)-6-N-tert-butoxycarbonylamino-8a-carboxyindolizidine methyl ester dissociation constant: above 0.2 mM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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