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Literature summary for 5.2.1.8 extracted from
- Interaction of human cyclophilin hCyp-18 with short peptides suggests the existence of two functionally independent subsites (2001), FEBS Lett., 505, 191-195.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-Ala-Pro-Phe-4-(trimethylammonium)anilide | IC50: 7 mM | Homo sapiens |  |
| acetyl-Ala-Pro-Phe-4-nitroanilide | IC50: 0.77 mM | Homo sapiens | |
| Ala-Pro | IC50: 30 mM | Homo sapiens | |
| succinyl-Ala-Ala-Pro-NH2 | IC50: 14 mM | Homo sapiens | |
| succinyl-Ala-Ala-Pro-Phe-4-carboxymethylanilide | IC50: 4.4 mM | Homo sapiens | |
| succinyl-Ala-Ala-Pro-Phe-4-nitroanilide | IC50: 0.54 mM | Homo sapiens | |
| succinyl-Ala-Pro-Phe-4-aminoanilide | IC50: 5.8 mM | Homo sapiens | |
| succinyl-Ala-Pro-Phe-4-carboxmethylanilide | IC50: 0.7 mM | Homo sapiens | |
| succinyl-Ala-Pro-Phe-4-nitroanilide | IC50: 0.17 mM | Homo sapiens | |
| succinyl-Pro-Phe-4-nitroanilide | IC50: 1.09 mM | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-Ala-Ala-(trans)-Pro-Arg-p-nitroanilide | - |
Homo sapiens | succinyl-Ala-Ala-(cis)-Pro-Arg-p-nitroanilide | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyclophilin hCyp-18 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.17 | - |
IC50: 0.17 mM | Homo sapiens | succinyl-Ala-Pro-Phe-4-nitroanilide | |
| 0.54 | - |
IC50: 0.54 mM | Homo sapiens | succinyl-Ala-Ala-Pro-Phe-4-nitroanilide | |
| 0.7 | - |
IC50: 0.7 mM | Homo sapiens | succinyl-Ala-Pro-Phe-4-carboxmethylanilide | |
| 0.77 | - |
IC50: 0.77 mM | Homo sapiens | acetyl-Ala-Pro-Phe-4-nitroanilide | |
| 1.09 | - |
IC50: 1.09 mM | Homo sapiens | succinyl-Pro-Phe-4-nitroanilide | |
| 4.4 | - |
IC50: 4.4 mM | Homo sapiens | succinyl-Ala-Ala-Pro-Phe-4-carboxymethylanilide | |
| 5.8 | - |
IC50: 5.8 mM | Homo sapiens | succinyl-Ala-Pro-Phe-4-aminoanilide | |
| 7 | - |
IC50: 7 mM | Homo sapiens | acetyl-Ala-Pro-Phe-4-(trimethylammonium)anilide | |
| 14 | - |
IC50: 14 mM | Homo sapiens | succinyl-Ala-Ala-Pro-NH2 | |
| 30 | - |
IC50: 30 mM | Homo sapiens | Ala-Pro | |
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