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Literature summary for 5.1.3.2 extracted from

  • Urbaniak, M.D.; Turnock, D.C.; Ferguson, M.A.
    Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4-epimerase conditional null mutant (2006), Eukaryot. Cell, 5, 1906-1913.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine Galactosylation of one or more glycoprotein(s), most likely in the endosomal/lysosomal system, is essential for the survival of bloodstream form Trypanosoma brucei. GalE-encoded epimerase and the downstream UDP-Gal transporters and UDP-Gal-dependent glycosyltransferases may be exploitable as drug targets. Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucose Trypanosoma brucei Galactose metabolism is essential for the survival of Trypanosoma brucei, the etiological agent of African sleeping sickness. UDP-alpha-D-galactose
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Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucose Galactose metabolism is essential for the survival of Trypanosoma brucei, the etiological agent of African sleeping sickness. Trypanosoma brucei UDP-alpha-D-galactose
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Synonyms

Synonyms Comment Organism
UDP-glucose 4'-epimerase
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Trypanosoma brucei