Application | Comment | Organism |
---|---|---|
medicine | the anti-tumour effects associated with ectopic GLCE re-expression suggest that it may be a potential tumour-suppressor gene and a possible target for lung cancer diagnosis and treatment | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in U2020 cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Heparosan-N-sulfate D-glucuronate | Homo sapiens | - |
Heparosan-N-sulfate L-iduronate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O94923 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
A-716 cell | - |
Homo sapiens | - |
H-157 cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
NCI-H157 cell | - |
Homo sapiens | - |
NCI-H647 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Heparosan-N-sulfate D-glucuronate | - |
Homo sapiens | Heparosan-N-sulfate L-iduronate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-glucuronyl C5-epimerase | - |
Homo sapiens |
Glce | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | D-glucuronyl C5-epimerase expression is decreased in lung cancer cells | down |
General Information | Comment | Organism |
---|---|---|
metabolism | D-glucuronyl C5-epimerase is a key enzyme involved in the biosynthesis of heparan sulfate proteoglycans, which has an important role in cell-cell and cell-matrix interactions and signaling | Homo sapiens |
physiological function | D-glucuronyl C5-epimerase inhibits U2020 tumor xenograft growth in vivo, the enzyme affects lung cancer cell proliferation and tumor growth by inhibiting tumor angiogenesis and invasion/metastasis pathways | Homo sapiens |