Activating Compound | Comment | Organism | Structure |
---|---|---|---|
BAY 41-2272 | sGC stimulant, relaxes newborn, but not adult bronchial muscle | Rattus norvegicus | |
sodium nitroprusside | NO donor, significant higher stimulation of sGC activity in newborns compared with adults | Rattus norvegicus | |
YC-1 | sGC stimulant, relaxes newborn, but not adult bronchial muscle | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
additional information | bronchial smooth muscle cGMP-, but not cAMP-dependent, relaxant response is developmentally regulated and significantly reduced in the adult rat, correlates with the higher expression of the two isoforms and higher activity of sGC in newborn rat bronchial tissue | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adult | 2-4 months old | Rattus norvegicus | - |
additional information | newborn aged 25 days | Rattus norvegicus | - |
smooth muscle | protein expression of the alpha1- and beta1-sGC isoforms is significantly lower in the adult compared with the newborn bronchial tissue | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Rattus norvegicus | 3',5'-cyclic AMP + diphosphate | - |
? | |
GTP | - |
Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Rattus norvegicus |
soluble guanylate cyclase | - |
Rattus norvegicus |