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Literature summary for 4.6.1.12 extracted from

  • Kumar, H.; Singh, K.; Kumar, S.
    2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase from Stevia rebaudiana Bertoni is a functional gene (2012), Mol. Biol. Rep., 39, 10971-10978.
    View publication on PubMed
Search for more literature for 4.6.1.12

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain EB370 Stevia rebaudiana

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24800
-
 x * 24800, calculated from amino acid sequence Stevia rebaudiana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol Stevia rebaudiana
-
 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP
-
 ?

Organism

Organism UniProt Comment Textmining
Stevia rebaudiana Q0Q5B3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 Stevia rebaudiana 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP
-
 ?

Subunits

Subunits Comment Organism
? x * 24800, calculated from amino acid sequence Stevia rebaudiana

Synonyms

Synonyms Comment Organism
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
-
 Stevia rebaudiana
MDS
-
 Stevia rebaudiana

pI Value

Organism Comment pI Value Maximum pI Value
Stevia rebaudiana calculated from amino acid sequence
-
 8.4

Expression

Organism Comment Expression
Stevia rebaudiana at 4°C, the enzyme expression is down-regulated at 0.05-0.1 mM indole 3-acetic acid. Methyl jasmonate and kinetin down-regulate the expression at 2 h and onwards down
Stevia rebaudiana abscisic acid does not modulate enzyme expression additional information
Stevia rebaudiana enzyme expression is higher in response to light as compared to plants kept under dark.The enzyme also exhibits a gradual up-regulation up to 6 h in response to gibberellic acid treatment up