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Literature summary for 4.4.1.5 extracted from

  • Helgager, J.; Li, J.; Lubensky, I.A.; Lonser, R.; Zhuang, Z.
    Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents (2010), J. Oncol., 2010, 373491.
    View publication on PubMedView publication on EuropePMC
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
23000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methylglyoxal + glutathione Homo sapiens
-
 (R)-S-lactoylglutathione
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-172 cell
-
 Homo sapiens
-
glioma cell
-
 Homo sapiens
-
U-251 cell
-
 Homo sapiens
-
U-373MG cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + glutathione
-
 Homo sapiens (R)-S-lactoylglutathione
-
 ?

Synonyms

Synonyms Comment Organism
GLO-1
-
 Homo sapiens
glyoxalase I
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
glutathione
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens troglitazone treatment (0.025-0.1 mM) reduces glyoxalase I protein expression in glioma down