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Literature summary for 4.4.1.5 extracted from

  • Kumagai, T.; Nangaku, M.; Inagi, R.
    Pathophysiological role of the glyoxalase system in renal hypoxic injury (2008), Ann. N. Y. Acad. Sci., 1126, 265-267.
    View publication on PubMed
Search for more literature for 4.4.1.5

Cloned(Commentary)

Cloned (Comment) Organism
rats, overexpressing human GLO I show e.g. improvement of the tubulointerstitial injury and renal function Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the glyoxalase system detoxifies methylglyoxal and is composed of two enzymes: glyoxylase I (GLO I), which metabolizes methylglyoxal to S-D-lactoylglutathione, and glyoxalase II (GLO II, EC 3.1.2.6) which converts S-D-lactoylglutathione to D-lactate ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Reaction

Reaction Comment Organism Reaction ID
(R)-S-lactoylglutathione = glutathione + 2-oxopropanal investigation of the biological role of GLO I in renal hypoxic diseases by using the rat ischemia/reperfusion (I/R) injury model. I/R induces the reduction of renal GLO I activity associated with morphological changes and renal dysfunction Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
additional information ischemia/reperfusion induces the reduction of GLO I activity in the kidney, which is asssociated with morphological damage and renal dysfunction Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 ischemia/reperfusion induces the reduction of GLO I activity in the kidney, which is asssociated with morphological damage and renal dysfunction Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + methylglyoxal methylglyoxal is a reactive dicarbonyl compound mainly produced by metabolic pathways such as glycolysis, binds to proteins or nucelic acids and forms advanced glycation end products Rattus norvegicus S-((R)-lactoyl)glutathione
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 ?
additional information the glyoxalase system detoxifies methylglyoxal and is composed of two enzymes: glyoxylase I (GLO I), which metabolizes methylglyoxal to S-D-lactoylglutathione, and glyoxalase II (GLO II, EC 3.1.2.6) which converts S-D-lactoylglutathione to D-lactate Rattus norvegicus ?
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 ?