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Literature summary for 4.4.1.5 extracted from

  • Korybalska, K.; Wisniewska-Elnur, J.; Trominska, J.; Joerres, A.; Breborowicz, A.; Witowski, J.
    The role of the glyoxalase pathway in reducing mesothelial toxicity of glucose degradation products (2006), Perit. Dial. Int., 26, 259-265.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information exposure of HPMC cells to heat-sterilized peritoneal dialysis fluids results in reduced GLO-I activity, GSH depletion, and a decrease in cell viability. Pretreatment of heat-sterilized peritoneal dialysis with either a combination of GLO-I and GSH markedly reduces inhibitory effects toward HPMC cells. Exposure of HPMC cells to L-2-oxothiazolidine-carboxylic acid increases cellular GSH and prevents loss of GLO-I activity in response to heat-sterilized peritoneal dialysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information HPMC cell Homo sapiens
-

Synonyms

Synonyms Comment Organism
GLO-I
-
Homo sapiens
glyoxalase I
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Homo sapiens