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Literature summary for 4.4.1.5 extracted from

  • Miller, A.G.; Smith, D.G.; Bhat, M.; Nagaraj, R.H.
    Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions (2006), J. Biol. Chem., 281, 11864-11871.
    View publication on PubMed
Search for more literature for 4.4.1.5

Application

Application Comment Organism
medicine glyoxalase I is critical for pericyte survival under hyperglycemic conditions, its inactivation and/or down-regulation by NO donor may contribute to pericyte death by apoptosis during early stages of diabetic retinopathy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into vector pCMS-EGFP, overexpression in HRP cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate decreases glyoxalase I expression and activity relative to untreated control cells, cells undergo apoptosis, apoptosis increases further on co-incubation with high glucose Homo sapiens
S-4-bromobenzylglutathione cyclopentyl diester detanonoate, NO donor, competitive inhibitor, concentration-dependent down-regulation of glyoxalase I, increases intracellular methylglyoxal and causes apoptosis, overexpression of glyoxalase I protects against S-4-bromobenzylglutathione cyclopentyl diester-induced apoptosis under high glucose conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information HRP cell Homo sapiens
-
pericyte
-
 Homo sapiens
-
retina
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + methylglyoxal
-
 Homo sapiens S-D-lactoylglutathione
-
 ?

Synonyms

Synonyms Comment Organism
glyoxalase I
-
 Homo sapiens