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Literature summary for 4.4.1.5 extracted from

  • Korithoski, B.; Levesque, C.M.; Cvitkovitch, D.G.
    Involvement of the detoxifying enzyme lactoylglutathione lyase in Streptococcus mutans aciduricity (2007), J. Bacteriol., 189, 7586-7592.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.4.1.5

Activating Compound

Activating Compound Comment Organism Structure
methylglyoxal addition at pH 5.0 results in a significant 98% increase in the glycolytic rate Streptococcus mutans
additional information is up-regulated during acid challenge, is induced during acidic growth 3.5fold and following acid adaptation 2fold, is up-regulated approximately 7fold during the exponential growth phase compared with that in the stationary growth phase Streptococcus mutans

Application

Application Comment Organism
medicine role in dental caries, LGL functions in the detoxification of methylglyoxal, resulting in increased aciduricity Streptococcus mutans

Protein Variants

Protein Variants Comment Organism
additional information lgl isogenic knockout mutant LGLKO, has no detectable enzyme activity, results in an acid-sensitive phenotype, glycolytic rate at pH 5.0 is higher for the mutant than for wild-type Streptococcus mutans

Inhibitors

Inhibitors Comment Organism Structure
methylglyoxal addition at pH 7.0 results in a modest 28% decrease in the glycolytic rate Streptococcus mutans

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
-
-
Streptococcus mutans UA159
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
46.2
-
 wild-type, at pH 5.0 Streptococcus mutans
68.7
-
 mutant, at pH 5.0 Streptococcus mutans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + methylglyoxal
-
 Streptococcus mutans S-D-lactoylglutathione
-
 ?
glutathione + methylglyoxal
-
 Streptococcus mutans UA159 S-D-lactoylglutathione
-
 ?

Synonyms

Synonyms Comment Organism
LGL
-
 Streptococcus mutans

pH Range

pH Minimum pH Maximum Comment Organism
5 7.5 lgl mRNA levels are 3.5fold higher in cells grown at pH 5.0 than in cells grown at pH 7.5, levels of lgl transcript are increased 2.1fold in cells exposed to pH 5.5 for 2 h Streptococcus mutans