Inhibitors | Comment | Organism | Structure |
---|---|---|---|
S-nitroso-N-acetyl-D,L-penicillamine | released NO inhibits glyoxalase I by reversible modification at a critical thiol residue, inactivation is reversed by reducing agents | Homo sapiens | |
S-nitrosocysteine | released NO inhibits glyoxalase I by reversible modification at a critical thiol residue, inactivation is reversed by reducing agents | Homo sapiens | |
S-nitrosoglutathione | glyoxal I activity in cells decreases rapidly within 30 min and reaches 10% of the control level within 2 h, activity returns to approx. 80% and 70% after removal of S-nitrosoglutathione or incubation with dithiothreitol, respectively, released NO inhibits glyoxalase I by reversible modification at a critical thiol residue, inactivation is reversed by reducing agents | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione-methylglyoxal hemithioacetal | Homo sapiens | glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione | (R)-S-lactoylglutathione | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione-methylglyoxal hemithioacetal | glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione | Homo sapiens | (R)-S-lactoylglutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glyoxalase I | - |
Homo sapiens |