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Literature summary for 4.3.3.7 extracted from

  • Phenix, C.P.; Nienaber, K.; Tam, P.H.; Delbaere, L.T.; Palmer, D.R.
    Structural, functional and calorimetric investigation of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti l5-30, does not support involvement in rhizopine biosynthesis (2008), ChemBioChem, 9, 1591-1602.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of MosA protein solved to 1.95 A resolution, data collection and refinement statistics Sinorhizobium meliloti

Inhibitors

Inhibitors Comment Organism Structure
2-oxobutyrate forms a Schiff base with MosA protein, competitive inhibition Sinorhizobium meliloti

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate 4-semialdehyde + pyruvate Sinorhizobium meliloti
-
dihydrodipicolinate + H2O
-
?
L-aspartate 4-semialdehyde + pyruvate Sinorhizobium meliloti L5-30
-
dihydrodipicolinate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Sinorhizobium meliloti Q07607 L5-30
-
Sinorhizobium meliloti L5-30 Q07607 L5-30
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
analysis of ability of rhizopines to interact with MosA protein in the presence and absence of methyl donors, no methyltransferase activity observed in the presence of scyllo-inosamine and S-adenosylmethionine (SAM), presence of rhizopine compounds does not affect kinetics of dihydrodipicolinate synthesis Sinorhizobium meliloti

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate 4-semialdehyde + pyruvate
-
Sinorhizobium meliloti dihydrodipicolinate + H2O
-
?
L-aspartate 4-semialdehyde + pyruvate isothermal titration calorimetry (ITC) to study Schiff base formation between an enzyme and its substrate, pyruvate condenses with an active site lysine residue (Lys161 in MosA) Sinorhizobium meliloti dihydrodipicolinate + H2O
-
?
L-aspartate 4-semialdehyde + pyruvate
-
Sinorhizobium meliloti L5-30 dihydrodipicolinate + H2O
-
?
L-aspartate 4-semialdehyde + pyruvate isothermal titration calorimetry (ITC) to study Schiff base formation between an enzyme and its substrate, pyruvate condenses with an active site lysine residue (Lys161 in MosA) Sinorhizobium meliloti L5-30 dihydrodipicolinate + H2O
-
?

Synonyms

Synonyms Comment Organism
DHDPS
-
Sinorhizobium meliloti
MosA protein
-
Sinorhizobium meliloti

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
isothermal titration microcalorimetry at Sinorhizobium meliloti