Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.3.3.7 extracted from

  • Mitsakos, V.; Dobson, R.C.; Pearce, F.G.; Devenish, S.R.; Evans, G.L.; Burgess, B.R.; Perugini, M.A.; Gerrard, J.A.; Hutton, C.A.
    Inhibiting dihydrodipicolinate synthase across species: Towards specificity for pathogens? (2007), Bioorg. Med. Chem. Lett., 18, 842-844.
    View publication on PubMed
Search for more literature for 4.3.3.7

Application

Application Comment Organism
medicine development of species-specific inhibitors of DHDPS as potential antibacterials Staphylococcus aureus
medicine development of species-specific inhibitors of DHDPS as potential antibacterials Escherichia coli
medicine development of species-specific inhibitors of DHDPS as potential antibacterials Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
(2R,6S)-piperidine-2,6-dicarboxylic acid 20 mM, 49% inhibition Escherichia coli
(2R,6S)-piperidine-2,6-dicarboxylic acid 20 mM, 43% inhibition; 20 mM, 77% inhibition Mycobacterium tuberculosis
(2R,6S)-piperidine-2,6-dicarboxylic acid 20 mM, 51% inhibition Staphylococcus aureus
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid
-
 Escherichia coli
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid 20 mM, 73% inhibition Mycobacterium tuberculosis
4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid 20 mM, 83% inhibition Staphylococcus aureus
cis-(1SS,3R5S)-3,5-thiomorpholinedicarboxylic acid, dimethyl ester, 1-oxide 20 mM, 8% inhibition Escherichia coli
cis-(1SS,3R5S)-3,5-thiomorpholinedicarboxylic acid, dimethyl ester, 1-oxide 20 mM, 8% inhibition Mycobacterium tuberculosis
cis-(1SS,3R5S)-3,5-thiomorpholinedicarboxylic acid, dimethyl ester, 1-oxide 20 mM, 10% inhibition Staphylococcus aureus
dimethyl (2R,6S)-piperidine-2,6-dicarboxylate 20 mM, 92% inhibition Escherichia coli
dimethyl (2R,6S)-piperidine-2,6-dicarboxylate 20 mM, 24% inhibition; 20 mM, 99% inhibitione Mycobacterium tuberculosis
dimethyl (2R,6S)-piperidine-2,6-dicarboxylate 20 mM, 58% inhibition Staphylococcus aureus
dimethyl (3R,5R)-thiomorpholine-3,5-dicarboxylate 20 mM, 12% inhibition Escherichia coli
dimethyl (3R,5R)-thiomorpholine-3,5-dicarboxylate 20 mM, 19% inhibition Mycobacterium tuberculosis
dimethyl (3R,5R)-thiomorpholine-3,5-dicarboxylate 1,1-dioxide 20 mM, 14% inhibition Escherichia coli
dimethyl (3R,5R)-thiomorpholine-3,5-dicarboxylate 1,1-dioxide 20 mM, 6% inhibition; 20 mM, 7% inhibition Mycobacterium tuberculosis
dimethyl (3R,5R)-thiomorpholine-3,5-dicarboxylate 1-oxide 20 mM, 7% inhibition Mycobacterium tuberculosis
dimethyl (3R,5R)-thiomorpholine-3,5-dicarboxylate 1-oxide 20 mM, 7% inhibition Staphylococcus aureus
dimethyl (3R,5S)-thiomorpholine-3,5-dicarboxylate 20 mM, 35% inhibition Escherichia coli
dimethyl (3R,5S)-thiomorpholine-3,5-dicarboxylate 20 mM, 23% inhibition Mycobacterium tuberculosis
dimethyl (3R,5S)-thiomorpholine-3,5-dicarboxylate 1,1-dioxide 20 mM, 19% inhibition; 20 mM, 6% inhibition Mycobacterium tuberculosis
dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate
-
 Escherichia coli
dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate 20 mM, 84% inhibition Mycobacterium tuberculosis
dimethyl 4-oxo-1,4-dihydropyridine-2,6-dicarboxylate 20 mM, 88% inhibition Staphylococcus aureus
dimethyl pyridine-2,6-dicarboxylate 20 mM, 5% inhibition Escherichia coli
dimethyl pyridine-2,6-dicarboxylate 20 mM, 13% inhibition Mycobacterium tuberculosis
pyridine-2,6-dicarboxylic acid
-
 Escherichia coli
pyridine-2,6-dicarboxylic acid 20 mM, 75% inhibition; 20 mM, 80% inhibition Mycobacterium tuberculosis
pyridine-2,6-dicarboxylic acid 20 mM, 67% inhibition Staphylococcus aureus
trans-(1SS,3R5S)-3,5-thiomorpholinedicarboxylic acid, dimethyl ester, 1-oxide 20 mM, 20% inhibition Escherichia coli
trans-(1SS,3R5S)-3,5-thiomorpholinedicarboxylic acid, dimethyl ester, 1-oxide 20 mM, 14% inhibition; 20 mM, 22% inhibition Mycobacterium tuberculosis
trans-(1SS,3R5S)-3,5-thiomorpholinedicarboxylic acid, dimethyl ester, 1-oxide 20 mM, 12% inhibition Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Mycobacterium tuberculosis
-
-
-
Staphylococcus aureus
-
 methicillin-resistant
-

Synonyms

Synonyms Comment Organism
DHDPS
-
 Escherichia coli
DHDPS
-
 Mycobacterium tuberculosis