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Literature summary for 4.3.3.7 extracted from

  • Couper, L.; McKendrick, J.E.; Robins, D.J.
    Pyridine and piperidine derivatives as inhibitors of dihydrdipicolinic acid synthase, a key enzyme in the diaminopimelate pathway to L-lysine (1994), Bioorg. Med. Chem. Lett., 4, 2267-2272.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
cis-piperidine-2,6-dicarboxylic acid and derivatives Escherichia coli
dipicolinic acid 1 mM, 50% inhibition Escherichia coli
dipicolinic acid di-imidate
-
Escherichia coli
dipicolinic acid N-oxide 0.8 mM 50% inhibition Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate-4-semialdehyde + pyruvate
-
Escherichia coli dihydrodipicolinate + H2O
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.8
-
dipicolinic acid N-oxide
-
Escherichia coli
1
-
dipicolinic acid
-
Escherichia coli