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Literature summary for 4.3.2.2 extracted from

  • Bierau, J.; Pooters, I.N.; Visser, D.; Bakker, J.A.
    An HPLC-based assay of adenylosuccinate lyase in erythrocytes (2011), Nucleosides Nucleotides Nucleic Acids, 30, 908-917.
    View publication on PubMed
Search for more literature for 4.3.2.2

Inhibitors

Inhibitors Comment Organism Structure
CuSO4 complete inhibition at 0.05 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0091
-
 succinyladenosine monophosphate wild-type enzyme, pH 8.1, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole Homo sapiens
-
 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate
-
 ?
succinyladenosine monophosphate Homo sapiens
-
 AMP + fumarate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole
-
 Homo sapiens 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate
-
 ?
additional information development of a rapid and simple HPLC-based assay method to quantitatively measure ADSL activity with succinyladenosine monophosphate in erythrocytes using isocratic ionpairing reversed-phase HPLC with UV-detection, overview Homo sapiens ?
-
 ?
succinyladenosine monophosphate
-
 Homo sapiens AMP + fumarate
-
 ?

Synonyms

Synonyms Comment Organism
ADSL
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction ADSL enzyme deficiency is a disorder of purine metabolism with a broad clinical spectrum. The enzyme deficit causes a highly variable clinical presentation varying from a relatively mild presentation with slight motor retardation and severe muscle hypotonia to severe neonatal onset convulsions accompanied by severe mental retardation Homo sapiens
metabolism the enzyme is a bifunctional protein that is involved in both purine de novo synthesis and purine interconversion. It catalyzes the formation of phosphoribosylaminoimidazole carboxamide and succinate from phosphoribosylsuccinyl-aminoimidazole carboxamide in the biosynthesis of IMP from phosphoribosylpyrophosphate. Alternatively, the enzyme catalyzes the synthesis of AMP and succinate from succinyl-AMP in the interconversion of IMP into AMP Homo sapiens