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Literature summary for 4.3.1.19 extracted from
- Threonine dehydratase from goat liver (1972), Arch. Biochem. Biophys., 151, 420-426.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cys | - |
Capra hircus |  |
| hydroxylamine | - |
Capra hircus | |
| Ile | no inhibition | Capra hircus | |
| iodoacetate | - |
Capra hircus | |
| L-Val | - |
Capra hircus | |
| Leu | - |
Capra hircus | |
| PCMB | - |
Capra hircus | |
| Ser | L-Ser, competitive with respect to L-Thr | Capra hircus | |
| Urea | - |
Capra hircus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 16 | - |
L-Thr | - |
Capra hircus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | stimulates | Capra hircus | |
| NH4+ | stimulates | Capra hircus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Capra hircus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Capra hircus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Capra hircus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.52 | - |
- |
Capra hircus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0-4°C, stable for at least 2 months | Capra hircus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-serine | no activity | Capra hircus | pyruvate + NH3 | - |
? | |
| L-threonine | - |
Capra hircus | 2-oxobutanoate + NH3 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 70 | - |
- |
Capra hircus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | 80 | 45°C: about 25% of maximal activity, 80°C: about 35% of maximal activity | Capra hircus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 9 | - |
Capra hircus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9.5 | pH 7.5: about 55% of maximal activity, pH 9.5: about 85% of maximal activity | Capra hircus |
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Release 2023.1 (January 2023)
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