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Literature summary for 4.2.99.18 extracted from

  • Charret, K.S.; Requena, C.E.; Castillo-Acosta, V.M.; Ruiz-Perez, L.M.; Gonzalez-Pacanowska, D.; Vidal, A.E.
    Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents (2012), DNA Repair, 11, 53-64.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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Trypanosoma brucei 449
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Synonyms

Synonyms Comment Organism
AP endonuclease 1
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 Trypanosoma brucei

General Information

General Information Comment Organism
physiological function isoform APE1-deficient cell lines derived from bloodstream stage trypanosomes, confirm that the AP endonuclease is not essential for viability in this cell type under in vitro culture conditions. An inverse correlation exists between the level of AP endonuclease in the cell and the number of endogenously generated abasic sites in its genomic DNA. Depletion of APE1 renders cells hypersensitive to AP site and strand break-inducing agents such as methotrexate and phleomycin, respectively, but not to alkylating agents. The increased susceptibility of APE1-depleted cells to nitric oxide suggests an essential role in protection against the immune defenses of the mammalian host Trypanosoma brucei