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Literature summary for 4.2.99.18 extracted from
- Probing conformational changes in Ape1 during the progression of base excision repair (2010), Biochemistry, 49, 3786-3796.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | DNA polymerase beta approaches the Ape1-DNA complex downstream of the incision site, displaces Ape1-DNA binding contacts including residues K227, K228, and K276, and in the process makes minimal interactions with lysine residues in the Ref1 domain, i.e. N-terminal residues 43-93 | Homo sapiens | ? | - |
? |  |
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Release 2023.1 (January 2023)
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