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Literature summary for 4.2.99.18 extracted from

  • Luo, M.; Kelley, M.R.
    Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone (2004), Anticancer Res., 24, 2127-2134.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
lucanthone inhibits repair activity from cellular extracts and enhances cell killing effect of the laboratory alkylating agent methyl methanesulfonate and the clinically relevant agent temozolomide, no inhibition of redox function or exonuclease activity on mismatched nucleotides Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
apurinic/apyrimidinic endonuclease APE1
-
Homo sapiens