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Literature summary for 4.2.99.18 extracted from

  • Xu, Y.j.; DeMott, M.S.; Hwang, J.T.; Greenberg, M.M.; Demple, B.
    Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA (2003), DNA Repair, 2, 175-185.
    View publication on PubMed
Search for more literature for 4.2.99.18

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000213
-
 DNA containing apurinic/apyrimidinic site pH 7.6, room temperature Homo sapiens
0.000098
-
 DNA with 2-deoxyribonolactone pH 7.6, room temperature Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Homo sapiens
-
 fragments of DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
 Homo sapiens fragments of DNA
-
 ?
DNA catalyzes 5'-incision of 2-deoxyribonolactone, but acts at least 10fold less effectively to remove the 3'-phosphates at direct strand breaks Homo sapiens fragments of DNA
-
 ?
DNA containing apurinic/apyrimidinic site
-
 Homo sapiens ?
-
 ?
DNA with 2-deoxyribonolactone
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3
-
 DNA with 2-deoxyribonolactone pH 7.6, room temperature Homo sapiens
2.4
-
 DNA containing apurinic/apyrimidinic site pH 7.6, room temperature Homo sapiens