Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.99.18 extracted from

  • Kow, Y.W.; Wallace, S.S.
    Mechanismm of action of Escherichia coli endonuclease III (1987), Biochemistry, 26, 8200-8206.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Mg2+ selectively inhibits endonuclease III activity when apurinic/apyrimidinic DNA is used as substrate, but has no effect when DNA containing either urea or thymine glycol is used as substrate Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000002
-
DNA containing thymine glycol pH 7.5, 30°C Escherichia coli
0.00000052
-
DNA containing apurinic sites pH 7.5, 30°C Escherichia coli
0.00000056
-
DNA containing urea pH 7.5, 30°C Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Escherichia coli
-
fragments of DNA
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
enzyme also has DNA N-glycosylase activity
-
Escherichia coli
-
endonuclease III
-

Reaction

Reaction Comment Organism Reaction ID
the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Escherichia coli fragments of DNA
-
?
DNA when DNA containing thymine glycol is used as substrate the combined N-glycosylase/AP endonuclease activity is about 2fold higher than the AP endonuclease activity Escherichia coli fragments of DNA
-
?
DNA containing apurinic sites
-
Escherichia coli ?
-
?
DNA containing thymine glycol
-
Escherichia coli ?
-
?
DNA containing urea
-
Escherichia coli ?
-
?
additional information enzyme also has DNA N-glycosylase activity Escherichia coli ?
-
?