Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | selectively inhibits endonuclease III activity when apurinic/apyrimidinic DNA is used as substrate, but has no effect when DNA containing either urea or thymine glycol is used as substrate | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000002 | - |
DNA containing thymine glycol | pH 7.5, 30°C | Escherichia coli | |
0.00000052 | - |
DNA containing apurinic sites | pH 7.5, 30°C | Escherichia coli | |
0.00000056 | - |
DNA containing urea | pH 7.5, 30°C | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | Escherichia coli | - |
fragments of DNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
enzyme also has DNA N-glycosylase activity | - |
Escherichia coli | - |
endonuclease III | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate | mechanism | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | - |
Escherichia coli | fragments of DNA | - |
? | |
DNA | when DNA containing thymine glycol is used as substrate the combined N-glycosylase/AP endonuclease activity is about 2fold higher than the AP endonuclease activity | Escherichia coli | fragments of DNA | - |
? | |
DNA containing apurinic sites | - |
Escherichia coli | ? | - |
? | |
DNA containing thymine glycol | - |
Escherichia coli | ? | - |
? | |
DNA containing urea | - |
Escherichia coli | ? | - |
? | |
additional information | enzyme also has DNA N-glycosylase activity | Escherichia coli | ? | - |
? |