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Literature summary for 4.2.3.12 extracted from
- Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus, Mortierella alpina (2011), Microbiology, 157, 3059-3070.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Mortierella alpina |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | complete inhibition | Mortierella alpina |  |
| Cu2+ | complete inhibition | Mortierella alpina | |
| Fe2+ | slight inhibition | Mortierella alpina | |
| Mn2+ | complete inhibition | Mortierella alpina | |
| additional information | not inhibitory: dithiothreitol | Mortierella alpina |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.164 | - |
7,8-dihydroneopterin triphosphate | pH 7.5, 25°C | Mortierella alpina | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 75% enhancement | Mortierella alpina | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 21000 | - |
* 21000, SDS-PAGE | Mortierella alpina |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mortierella alpina | G3FNL7 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant protein | Mortierella alpina |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,8-dihydroneopterin triphosphate | - |
Mortierella alpina | 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | * 21000, SDS-PAGE | Mortierella alpina |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PTPS | - |
Mortierella alpina |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Mortierella alpina |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 5 | - |
70% of maximum activity | Mortierella alpina |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Mortierella alpina |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 10 | - |
Mortierella alpina |
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Release 2023.1 (January 2023)
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