Literature summary for 4.2.1.45 extracted from

Matsuhashi, S.; Matsuhashi, M.; Brown, J.G.; Strominger, J.L.
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3. Cytidine diphosphate D-glucose oxidoreductase (1966), J. Biol. Chem., 241, 4283-4287.

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General Stability

General Stability	Organism
unstable to intermittant freezing and thawing	Yersinia pseudotuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
CDP-4-keto-6-deoxy-D-glucose	-	Yersinia pseudotuberculosis
p-chloromercuriphenylsulfonate	-	Yersinia pseudotuberculosis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.017	-	CDP-D-glucose	-	Yersinia pseudotuberculosis

Organism

Organism	UniProt	Comment	Textmining
Yersinia pseudotuberculosis	-	Pasteurella pseudotuberculosis	-

Purification (Commentary)

Purification (Comment)	Organism
partial	Yersinia pseudotuberculosis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.445	-	-	Yersinia pseudotuberculosis

Storage Stability

Storage Stability	Organism
-20°C, 0.02 M phosphate buffer, pH 7.5, several months, stable	Yersinia pseudotuberculosis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CDP-D-glucose	-	Yersinia pseudotuberculosis	CDP-4-dehydro-6-deoxy-D-glucose + H2O	-	ir
dCDP-D-glucose	-	Yersinia pseudotuberculosis	dCDP-4-dehydro-6-deoxy-D-glucose + H2O	-	ir

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
-	-	unstable at	Yersinia pseudotuberculosis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	8.5	-	Yersinia pseudotuberculosis

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	required	Yersinia pseudotuberculosis

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Release 2023.1 (January 2023)