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Literature summary for 4.2.1.36 extracted from

  • Milewska, M.; Prokop, M.; Gabriel, I.; MilewskiWojciechowski, M.; Milewski, S.
    Antifungal activity of homoaconitate and homoisocitrate analogs (2012), Molecules, 17, 14022-14036.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information trimethyl trans-homoaconitate, trimethyl (1E)1,2-epoxy-butane-1,2,4-tricarboxylate, dimethyl (2S,3R)-2-hydroxy-3-propylsuccinate, dimethyl (2S,3R)-2-hydroxy-3-butylsuccinate, dimethyl (2S,3R)-2-hydroxy-3-allylsuccinate, dimethyl (2R,3S)-2-fluoro-3-propylsuccinate, dimethyl (2R,3S)-2-fluoro-3-butylsuccinate, dimethyl (2R,3S)-2-fluoro-3-allylsuccinate, trimethyl (2R,3S)-2-fluoro-2-deoxyhomoisocitrate, dipotassium (2R,3S)-2-fluoro-3-allylsuccinate, and tripotassium (2R,3S)-2-fluoro-2-deoxyhomoisocitrate have no effect on enzyme activity at concentrations up to 10 mM Candida albicans
trans-homoaconitate
-
Candida albicans
tripotassium (1E)1,2-epoxy-butane-1,2,4-tricarboxylate
-
Candida albicans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5
-
(R)-homocitrate in 50 mM Tris-HCl (pH 8.5), 50 mM KCl, 5 mM MgCl2, 20 mM dithiothreitol, at 20°C Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate Candida albicans
-
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate
-
Candida albicans (Z)-but-1-ene-1,2,4-tricarboxylate + H2O
-
?
(R)-homocitrate
-
Candida albicans ?
-
?

Synonyms

Synonyms Comment Organism
Homoaconitase
-
Candida albicans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.58
-
in 50 mM Tris-HCl (pH 8.5), 50 mM KCl, 5 mM MgCl2, 20 mM dithiothreitol, at 20°C Candida albicans trans-homoaconitate
5.76
-
in 50 mM Tris-HCl (pH 8.5), 50 mM KCl, 5 mM MgCl2, 20 mM dithiothreitol, at 20°C Candida albicans tripotassium (1E)1,2-epoxy-butane-1,2,4-tricarboxylate