Literature summary for 4.2.1.30 extracted from

Sakai, T.; Yamasaki, A.; Toyofuku, S.; Nishiki, T.; Yunoki, M.; Komoto, N.; Tobimatsu, T.; Toraya, T.
Construction and characterization of hybrid dehydratases between adenosylcobalamin-dependent diol and glycerol dehydratases (2007), J. Nutr. Sci. Vitaminol., 53, 102-108.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Klebsiella pneumoniae

Inhibitors

Inhibitors	Comment	Organism	Structure
glycerol	suicide inactivation	Klebsiella pneumoniae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.32	-	1,2-propanediol	-	Klebsiella pneumoniae
1.1	-	glycerol	-	Klebsiella pneumoniae

Metals/Ions

Metals/Ions	Comment	Organism	Structure
K+	bound in the inner part of the triose phosphate isomereas barrel of the alpha-subunit	Klebsiella pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
120	-	-	Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,2-propanediol	-	Klebsiella pneumoniae	propionaldehyde + H2O	-	?
glycerol	-	Klebsiella pneumoniae	3-hydroxypropionaldehyde + H2O	-	?

Subunits

Subunits	Comment	Organism
trimer	(alpha/beta/gamma)2-structure, alpha 60000-61000 Da, beta 21000-24000 Da, gamma 16000-19000 Da	Klebsiella pneumoniae

Synonyms

Synonyms	Comment	Organism
glycerol dehydratase	-	Klebsiella pneumoniae

Cofactor

Cofactor	Comment	Organism	Structure
coenzyme B12	-	Klebsiella pneumoniae

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Release 2023.1 (January 2023)