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Literature summary for 4.2.1.30 extracted from
- Molecular basis for specificities of reactivating factors for adenosylcobalamin-dependent diol and glycerol dehydratases (2007), FEBS J., 274, 5556-5566.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Klebsiella pneumoniae |  |
| ATP | - |
Klebsiella oxytoca | |
| glycerol dehydratase-reactivating factor | - |
Klebsiella pneumoniae | |
| glycerol dehydratase-reactivating factor | - |
Klebsiella oxytoca |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpressed in Escherichia coli | Klebsiella pneumoniae |
| overexpressed in Escherichia coli | Klebsiella oxytoca |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Klebsiella pneumoniae |
- |
Klebsiella oxytoca |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycerol | suicide inactivation | Klebsiella oxytoca | |
| glycerol | suicide inactivation | Klebsiella pneumoniae | |
| O2 | in absence of substrate | Klebsiella oxytoca | |
| O2 | in absence of substrate | Klebsiella pneumoniae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | essential for glycerol dehydratase-reactivating factor | Klebsiella pneumoniae | |
| Mg2+ | essential for glycerol dehydratase-reactivating factor | Klebsiella oxytoca | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycerol | Klebsiella pneumoniae | - |
3-hydroxypropanal + H2O | - |
? | |
| glycerol | Klebsiella oxytoca | - |
3-hydroxypropanal + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella oxytoca | - |
- |
- |
| Klebsiella pneumoniae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Klebsiella pneumoniae |
- |
Klebsiella oxytoca |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycerol | - |
Klebsiella pneumoniae | 3-hydroxypropanal + H2O | - |
? | |
| glycerol | - |
Klebsiella oxytoca | 3-hydroxypropanal + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | a large subunit (alpha) of 64000 Da and a small subunit (beta) of 14000 Da | Klebsiella pneumoniae |
| dimer | a large subunit (alpha) of 64000 Da and a small subunit (beta) of 14000 Da | Klebsiella oxytoca |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycerol dehdydrogenase | - |
Klebsiella pneumoniae |
| glycerol dehdydrogenase | - |
Klebsiella oxytoca |
| glycerol hydro-lyase | - |
Klebsiella pneumoniae |
| glycerol hydro-lyase | - |
Klebsiella oxytoca |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| adenosylcobalamin | - |
Klebsiella pneumoniae | |
| adenosylcobalamin | - |
Klebsiella oxytoca | |
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Release 2023.1 (January 2023)
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