Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q9ER34 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
midbrain | mitochondrial aconitase is over-expressed in primary mesencephalic cultures | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
aconitase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | it is investigated if oxidative inactivation of mitochondrial aconitase results in the release of redox-active iron and hydrogen peroxide and whether this contributes to cell death. Using an adenoviral construct mitochondrial aconitase is over-expressed in primary mesencephalic cultures. Oxidative inactivation of m-aconitase over-expressing cultures results in exacerbation of H2O2 production, Fe2+ accumulation and increased neuronal death. Increased cell death in m-aconitase overexpressing cultures is attenuated by addition of catalase and/or a cell permeable iron chelator suggesting that neuronal death occurred in part via astrocyte-derived H2O2 | Rattus norvegicus |