Application | Comment | Organism |
---|---|---|
medicine | enzyme inhibition, e.g. by deferiprone, is helpful in Friedreich's ataxia treatment | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
deferiprone | the loss of aconitase activity observed in cells should be ascribed to the chelation of available iron rather than to a direct effect of the chelator on the iron-sulfur clusters of the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
mitochondrion | mitochondrial aconitase activity represents up to 80% of the total aconitase activity in skin fibroblasts | Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required, the enzyme contains iron-sulfur clusters. Chelating mitochondrial free iron in various cell systems causes loss of aconitase activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | impairing aconitase activity precedes decreased cell proliferation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | impairing aconitase activity precedes decreased cell proliferation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aconitase | - |
Homo sapiens |