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Literature summary for 4.2.1.28 extracted from
- Molecular basis for specificities of reactivating factors for adenosylcobalamin-dependent diol and glycerol dehydratases (2007), FEBS J., 274, 5556-5566.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | needed for reactivation | Klebsiella pneumoniae |  |
| ATP | needed for reactivation | Klebsiella oxytoca | |
| diol dehydratase-reactivating factor | activates inactive enzymeCN-Cbl complexes, dimeric (alphabbeta) structurea large subunit of 64 kDa and a small subunit of 14 kDa | Klebsiella oxytoca | |
| diol dehydratase-reactivating factor | activates inactive enzymeCN-Cbl complexes, dimeric (alphabeta) structurea large subunit of 64000 Da and a small subunit of 14000 Da | Klebsiella pneumoniae |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Klebsiella pneumoniae |
| expression in Escherichia coli | Klebsiella oxytoca |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | needed for reactivation | Klebsiella pneumoniae | |
| Mg2+ | needed for reactivation | Klebsiella oxytoca | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella oxytoca | - |
- |
- |
| Klebsiella pneumoniae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Klebsiella pneumoniae |
- |
Klebsiella oxytoca |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-ethanediol | - |
Klebsiella pneumoniae | acetaldehyde + H2O | - |
? | |
| 1,2-ethanediol | - |
Klebsiella oxytoca | acetaldehyde + H2O | - |
? | |
| 1,2-propanediol | - |
Klebsiella pneumoniae | propanal + H2O | - |
? | |
| 1,2-propanediol | - |
Klebsiella oxytoca | propanal + H2O | - |
? | |
| glycerol | - |
Klebsiella pneumoniae | beta-hydroxypropionaldehyde + H2O | - |
? | |
| glycerol | - |
Klebsiella oxytoca | beta-hydroxypropionaldehyde + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 1,2-propanediol hydro-lyase | - |
Klebsiella pneumoniae |
| 1,2-propanediol hydro-lyase | - |
Klebsiella oxytoca |
| diol dehydratase | - |
Klebsiella pneumoniae |
| diol dehydratase | - |
Klebsiella oxytoca |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| adenosylcobalamin | - |
Klebsiella pneumoniae | |
| adenosylcobalamin | - |
Klebsiella oxytoca | |
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Release 2023.1 (January 2023)
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