Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Salmonella enterica subsp. enterica serovar Typhimurium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glycolaldehyde hydrate | induces the formation of cob(II)alamin and 5'-deoxyadenosine from adenosylcobalamin at the active site of the enzyme, and the resulting complex is inactive | Salmonella enterica subsp. enterica serovar Typhimurium |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
propane-1,2-diol = propanal + H2O | radical mechanism. Abstraction of a hydrogen atom from C1 of the substrate by the 5'-deoxyadenosyl radical produces a substrate radical which undergoes further transformation into the radical precursor of hydrated propionaldehyde. If dehydration of the radical is by acid catalysis, a resonance-stabilized radical cationic intermediate is formed. The radical cation is then hydrated to the radical precursor of propionaldehyde hydrate. If base catalysis takes place, a ketyl radical is initially generated, and it eliminates hydroxide to form a resonance-stabilized aldehyde radical. Addition of hydroxide to the aldehydic group generates the radical precursor to propionaldehyde hydrate. The planar cationic radical from acid-catalyzed dehydration can lose a proton to form the semidione radical. In the base-catalyzed dehydration, the ketyl radical can eliminate hydroxide to form the semidione radical | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-propanediol | - |
Salmonella enterica subsp. enterica serovar Typhimurium | propanal | - |
? | |
glycolaldehyde hydrate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ethandiol | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
coenzyme B12 | adenosylcobalamin. Radical initiator | Salmonella enterica subsp. enterica serovar Typhimurium |