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Literature summary for 4.2.1.24 extracted from

  • Brito, V.B.; Folmer, V.; Guerra, I.I.; Rocha, J.B.
    Kinetics of alloxan-induced inhibition on delta-aminolevulinate dehydratase activity in mouse liver homogenates (2012), Appl. Biochem. Biotechnol., 166, 1047-1056.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alloxan i.e. 2,4,5,6-tetraoxypyrimidine 5,6-dioxyuracil , 0.00125-0.02 mM alloxan causes a concentration-dependent uncompetitive inhibition. Dithiothreitol (0.7and 1 mM) completely prevents the inhibition induced by 0.01 and 0.02 mM alloxan. Similar protection is obtained in the presence of 2 mMglutathione Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-aminolevulinate Mus musculus
-
porphobilinogen + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-aminolevulinate
-
Mus musculus porphobilinogen + H2O
-
?

Synonyms

Synonyms Comment Organism
delta-ALA-D
-
Mus musculus
delta-aminolevulinate dehydrataseALAD
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00364
-
alloxan pH 6.4 and 37°C Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.004
-
pH 6.4 and 37°C Mus musculus alloxan

General Information

General Information Comment Organism
metabolism the enzyme catalyses the second step in heme biosynthesis Mus musculus