Literature summary for 4.2.1.24 extracted from

Selwood, T.; Tang, L.; Lawrence, S.H.; Anokhina, Y.; Jaffe, E.K.
Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase (2008), Biochemistry, 47, 3245-3257.

Search for more literature for 4.2.1.24

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
F12L	naturally occurring variant	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.02	-	5-aminolevulinic acid	wild type, pH 9, octamer	Homo sapiens
0.2	-	5-aminolevulinic acid	wild type, pH 7, almost octamer	Homo sapiens
4.5	-	5-aminolevulinic acid	wild type, pH 9, predominantly hexamer and/or dimer	Homo sapiens
4.6	-	5-aminolevulinic acid	F12L, pH 9	Homo sapiens
18	-	5-aminolevulinic acid	F12L, pH 7	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P13716	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.67	-	wild-type octamer	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-aminolevulinic acid + 5-aminolevulinic acid	-	Homo sapiens	porphobilinogen + 2 H2O	-	?

Subunits

Subunits	Comment	Organism
dimer	pro-hexamer dimer and pro-octamer dimer, analyzed by gel filtration	Homo sapiens
hexamer	wild type, pH 8.8, catalytic turnover favors octamer, analyzed by gel filtration and anion exchange chromatography	Homo sapiens
octamer	wild type, pH 6.9 and pH 8.8, analyzed by gel filtration and anion exchange chromatography	Homo sapiens

Synonyms

Synonyms	Comment	Organism
Porphobilinogen synthase	-	Homo sapiens

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Release 2023.1 (January 2023)